Pharm 6th Sem: Biopharmaceutics & Pharmacokinetics - Unit 1 Notes

Subject: Biopharmaceutics and Pharmacokinetics

Course: B. Pharmacy (6th Semester)

Topic: Unit I - Drug Protein Binding Detailed Index/Topics Covered:Introduction to Drug Binding: Overview of blood components (plasma proteins, RBCs) and extravascular tissues. Plasma Protein-Drug Binding: Detailed order of binding (Albumin, Glycoprotein, Lipoproteins, Globulins). Binding to Blood Cells: Specifics on RBC entry and binding to Hemoglobin and Carbonic Anhydrase. Extravascular Tissue Binding: Importance for Volume of Distribution (Vd) and specific tissue examples like Liver, Lungs, and Kidney. Kinetics of Protein Binding: Mathematical derivations using the Law of Mass Action. Graphical Plots: Comprehensive guide to determining binding constants using:

Direct Plot

Scatchard Plot

Klotz / Double Reciprocal Plot

Hitchcock Plot